Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function. Here, we tested the effect of furin on chondrocyte catabolism and the developme...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Lin, Hilène, Hay, Eric, Latourte, Augustin, Funck-Brentano, Thomas, Bouaziz, Wafa, Ea, Hang-Korng, Khatib, Abdel-Majid, Richette, Pascal, Cohen-Solal, Martine
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041273/
https://ncbi.nlm.nih.gov/pubmed/29992982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28713-2
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak