Discovery and characterization of small molecules that target the Ral GTPase

The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis(1). Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Nature
Hoofdauteurs: Yan, Chao, Liu, Degang, Li, Liwei, Wempe, Michael F., Guin, Sunny, Khanna, May, Meier, Jeremy, Hoffman, Brenton, Owens, Charles, Wysoczynski, Christina L., Nitz, Matthew D., Knabe, Eric W., Brautigan, David L., Paschal, Bryce M., Schwartz, Martin A., Jones, David, Ross, David, Meroueh, Samy O., Theodorescu, Dan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351747/
https://ncbi.nlm.nih.gov/pubmed/25219851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13713
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items