Discovery and characterization of small molecules that target the Ral GTPase

The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis(1). Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site...

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Publicado en:Nature
Autores principales: Yan, Chao, Liu, Degang, Li, Liwei, Wempe, Michael F., Guin, Sunny, Khanna, May, Meier, Jeremy, Hoffman, Brenton, Owens, Charles, Wysoczynski, Christina L., Nitz, Matthew D., Knabe, Eric W., Brautigan, David L., Paschal, Bryce M., Schwartz, Martin A., Jones, David, Ross, David, Meroueh, Samy O., Theodorescu, Dan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351747/
https://ncbi.nlm.nih.gov/pubmed/25219851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13713
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