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Discovery and characterization of small molecules that target the Ral GTPase
The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis(1). Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site...
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| Publicado en: | Nature |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351747/ https://ncbi.nlm.nih.gov/pubmed/25219851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13713 |
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