Discovery and characterization of small molecules that target the Ral GTPase

The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis(1). Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Yan, Chao, Liu, Degang, Li, Liwei, Wempe, Michael F., Guin, Sunny, Khanna, May, Meier, Jeremy, Hoffman, Brenton, Owens, Charles, Wysoczynski, Christina L., Nitz, Matthew D., Knabe, Eric W., Brautigan, David L., Paschal, Bryce M., Schwartz, Martin A., Jones, David, Ross, David, Meroueh, Samy O., Theodorescu, Dan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351747/
https://ncbi.nlm.nih.gov/pubmed/25219851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13713
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