Discovery and characterization of small molecules that target the Ral GTPase

The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis(1). Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site...

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Udgivet i:Nature
Main Authors: Yan, Chao, Liu, Degang, Li, Liwei, Wempe, Michael F., Guin, Sunny, Khanna, May, Meier, Jeremy, Hoffman, Brenton, Owens, Charles, Wysoczynski, Christina L., Nitz, Matthew D., Knabe, Eric W., Brautigan, David L., Paschal, Bryce M., Schwartz, Martin A., Jones, David, Ross, David, Meroueh, Samy O., Theodorescu, Dan
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351747/
https://ncbi.nlm.nih.gov/pubmed/25219851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13713
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