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The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer
Activating RAS mutations are common in human tumors. These mutations are often markers for resistance to therapy and subsequent poor prognosis. So far, targeting the RAF-MEK-ERK and PI3K-AKT signaling pathways downstream of RAS is the only promising approach in the treatment of cancer patients harbo...
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| Publié dans: | Acta Pharmacol Sin |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4349922/ https://ncbi.nlm.nih.gov/pubmed/25557115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.129 |
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