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The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer

Activating RAS mutations are common in human tumors. These mutations are often markers for resistance to therapy and subsequent poor prognosis. So far, targeting the RAF-MEK-ERK and PI3K-AKT signaling pathways downstream of RAS is the only promising approach in the treatment of cancer patients harbo...

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Detalles Bibliográficos
Publicado en:Acta Pharmacol Sin
Main Authors: Guin, Sunny, Theodorescu, Dan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349922/
https://ncbi.nlm.nih.gov/pubmed/25557115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.129
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