Ferroxitosis: A cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma

Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function. Concurrent attenuation of oxidative phosphorylation and HIF-1α/PKM2-dependent glycolysis promotes a non-apoptotic, iron- and o...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lakhter, Alexander J., Hamilton, James, Dagher, Pierre C., Mukkamala, Suresh, Hato, Takashi, Dong, X. Charlie, Mayo, Lindsey D., Harris, Robert A., Shekhar, Anantha, Ivan, Mircea, Brustovetsky, Nickolay, Naidu, Samisubbu R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350353/
https://ncbi.nlm.nih.gov/pubmed/25587028
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