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Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2

Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for cancer therapy. We report that unlike its structura...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Shankar Babu, Mani, Mahanta, Sailendra, Lakhter, Alexander J., Hato, Takashi, Paul, Subhankar, Naidu, Samisubbu R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796696/
https://ncbi.nlm.nih.gov/pubmed/29394289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191419
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