Golgi Associated HIF1a Serves as a Reserve in Melanoma Cells

Hypoxia-inducible factor-1alpha (HIF1a) is a key transcriptional regulator that enables cellular metabolic adaptation to low levels of oxygen. Multiple mechanisms, including lysosomal degradation, control the levels of HIF1a protein. Here we show that HIF1a protein degradation is resistant to lysoso...

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Bibliographic Details
Published in:J Cell Biochem
Main Authors: Lakhter, Alexander J., Lahm, Tim, Broxmeyer, Hal E., Naidu, Samisubbu R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831122/
https://ncbi.nlm.nih.gov/pubmed/26375488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25381
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