HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Malignant melanoma is characterized by a propensity for early lymphatic and hematogenous spread. The hypoxia-inducible factor (HIF) family of transcription factors is upregulated in melanoma by key oncogenic drivers. HIFs promote the activation of genes involved in cancer initiation, progression, an...

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Main Authors: Hanna, Sara C., Krishnan, Bhavani, Bailey, Sean T., Moschos, Stergios J., Kuan, Pei-Fen, Shimamura, Takeshi, Osborne, Lukas D., Siegel, Marni B., Duncan, Lyn M., O’Brien, E. Tim, Superfine, Richard, Miller, C. Ryan, Simon, M. Celeste, Wong, Kwok-Kin, Kim, William Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635738/
https://ncbi.nlm.nih.gov/pubmed/23563312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66715
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