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Inflammation, but not hypoxia, mediated HIF-1α activation depends on COX-2

The COX pathway has been a target for pharmaceutical intervention in diseases with a high inflammatory component ranging from asthma and Alzheimer's to arthritis and cancer. A major transcriptional promoter of the malignant phenotype, HIF-1α, has been observed to be regulated by the COX-2 produ...

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Bibliografske podrobnosti
Main Authors: Stasinopoulos, Ioannis, O'Brien, David R., Bhujwalla, Zaver M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058789/
https://ncbi.nlm.nih.gov/pubmed/19390242
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