Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in ent...

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Vydáno v:J Clin Invest
Hlavní autoři: Degagné, Emilie, Pandurangan, Ashok, Bandhuvula, Padmavathi, Kumar, Ashok, Eltanawy, Abeer, Zhang, Meng, Yoshinaga, Yuko, Nefedov, Mikhail, de Jong, Pieter J., Fong, Loren G., Young, Stephen G., Bittman, Robert, Ahmedi, Yasmin, Saba, Julie D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348973/
https://ncbi.nlm.nih.gov/pubmed/25347472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74188
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