Human glial chimeric mice reveal astrocytic dependence of JC virus infection

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease triggered by infection with the human gliotropic JC virus (JCV). Due to the human-selective nature of the virus, there are no animal models available to investigate JCV pathogenesis. To address this issue, we developed mice...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Kondo, Yoichi, Windrem, Martha S., Zou, Lisa, Chandler-Militello, Devin, Schanz, Steven J., Auvergne, Romane M., Betstadt, Sarah J., Harrington, Amy R., Johnson, Mahlon, Kazarov, Alexander, Gorelik, Leonid, Goldman, Steven A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348956/
https://ncbi.nlm.nih.gov/pubmed/25401469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76629
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