Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia

In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells derived from patients with childhood...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Windrem, Martha S., Osipovitch, Mikhail, Liu, Zhengshan, Bates, Janna, Chandler-Militello, Devin, Zou, Lisa, Munir, Jared, Schanz, Steven, McCoy, Katherine, Miller, Robert H., Wang, Su, Nedergaard, Maiken, Findling, Robert L., Tesar, Paul J., Goldman, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576346/
https://ncbi.nlm.nih.gov/pubmed/28736215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.06.012
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