Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia

In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells derived from patients with childhood...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Windrem, Martha S., Osipovitch, Mikhail, Liu, Zhengshan, Bates, Janna, Chandler-Militello, Devin, Zou, Lisa, Munir, Jared, Schanz, Steven, McCoy, Katherine, Miller, Robert H., Wang, Su, Nedergaard, Maiken, Findling, Robert L., Tesar, Paul J., Goldman, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576346/
https://ncbi.nlm.nih.gov/pubmed/28736215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.06.012
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