Human iPSC-derived oligodendrocyte progenitors can myelinate and rescue a mouse model of congenital hypomyelination

Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of congenitally dysmyelinated brain. To establish a potential autologous source of these cells, we developed a strategy by which to differentiate human induced pluripotential stem cells (hiPSCs) into OPCs. From 3...

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Detalhes bibliográficos
Main Authors: Wang, Su, Bates, Janna, Li, Xiaojie, Schanz, Steven, Chandler-Militello, Devin, Levine, Corri, Maherali, Nimet, Studer, Lorenz, Hochedlinger, Konrad, Windrem, Martha, Goldman, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700553/
https://ncbi.nlm.nih.gov/pubmed/23395447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.12.002
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