DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior

The small guanosine triphosphatase Rab13 functions in exocytic vesicle trafficking in epithelial cells. Alterations in Rab13 activity have been observed in human cancers, yet the mechanism of Rab13 activation and its role in cancer progression remain unclear. In this paper, we identify the DENN doma...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Ioannou, Maria S., Bell, Emily S., Girard, Martine, Chaineau, Mathilde, Hamlin, Jason N.R., Daubaras, Mark, Monast, Anie, Park, Morag, Hodgson, Louis, McPherson, Peter S.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347646/
https://ncbi.nlm.nih.gov/pubmed/25713415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201407068
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