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Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy
Unc-51-like kinases (ULKs) are the most upstream kinases in the initiation of autophagy, yet the molecular mechanisms underlying their function are poorly understood. We report a new role for ULK in the induction of autophagy. ULK-mediated phosphorylation of the guanine nucleotide exchange factor DE...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4467855/ https://ncbi.nlm.nih.gov/pubmed/25925668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201440006 |
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