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Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy

Unc-51-like kinases (ULKs) are the most upstream kinases in the initiation of autophagy, yet the molecular mechanisms underlying their function are poorly understood. We report a new role for ULK in the induction of autophagy. ULK-mediated phosphorylation of the guanine nucleotide exchange factor DE...

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Bibliografske podrobnosti
izdano v:EMBO Rep
Main Authors: Xu, Jie, Fotouhi, Maryam, McPherson, Peter S
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467855/
https://ncbi.nlm.nih.gov/pubmed/25925668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201440006
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