Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

Platelet aggregation at sites of vascular injury is essential for hemostasis but also thrombosis. Platelet adhesiveness is critically dependent on agonist-induced inside-out activation of heterodimeric integrin receptors by a mechanism involving the recruitment of talin-1 to the cytoplasmic integrin...

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Detalles Bibliográficos
Publicado en:Blood
Autores principales: Stritt, Simon, Wolf, Karen, Lorenz, Viola, Vögtle, Timo, Gupta, Shuchi, Bösl, Michael R., Nieswandt, Bernhard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Plenary Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347307/
https://ncbi.nlm.nih.gov/pubmed/25336629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-597542
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