Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

Platelet aggregation at sites of vascular injury is essential for hemostasis but also thrombosis. Platelet adhesiveness is critically dependent on agonist-induced inside-out activation of heterodimeric integrin receptors by a mechanism involving the recruitment of talin-1 to the cytoplasmic integrin...

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Bibliographic Details
Published in:Blood
Main Authors: Stritt, Simon, Wolf, Karen, Lorenz, Viola, Vögtle, Timo, Gupta, Shuchi, Bösl, Michael R., Nieswandt, Bernhard
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347307/
https://ncbi.nlm.nih.gov/pubmed/25336629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-597542
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