Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

Platelet aggregation at sites of vascular injury is essential for hemostasis but also thrombosis. Platelet adhesiveness is critically dependent on agonist-induced inside-out activation of heterodimeric integrin receptors by a mechanism involving the recruitment of talin-1 to the cytoplasmic integrin...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Stritt, Simon, Wolf, Karen, Lorenz, Viola, Vögtle, Timo, Gupta, Shuchi, Bösl, Michael R., Nieswandt, Bernhard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2015
Onderwerpen:
Plenary Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347307/
https://ncbi.nlm.nih.gov/pubmed/25336629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-597542
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