Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy

Patients with type 2 diabetes often present with cardiovascular complications; however, it is not clear how diabetes promotes cardiac dysfunction. In murine models, deletion of the gene encoding aryl hydrocarbon nuclear translocator (ARNT, also known as HIF1β) in the liver or pancreas leads to a dia...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Chawla, Kusum, Tran, Minh, Chai, Xiaomeng, Wagg, Cory, Ghanefar, Mohsen, Jiang, Xinghang, Bayeva, Marina, Gonzalez, Frank, Lopaschuk, Gary, Ardehali, Hossein
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347233/
https://ncbi.nlm.nih.gov/pubmed/25329697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76737
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