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Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
Doxorubicin is an effective anticancer drug with known cardiotoxic side effects. It has been hypothesized that doxorubicin-dependent cardiotoxicity occurs through ROS production and possibly cellular iron accumulation. Here, we found that cardiotoxicity develops through the preferential accumulation...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904631/ https://ncbi.nlm.nih.gov/pubmed/24382354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72931 |
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