Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy

Patients with type 2 diabetes often present with cardiovascular complications; however, it is not clear how diabetes promotes cardiac dysfunction. In murine models, deletion of the gene encoding aryl hydrocarbon nuclear translocator (ARNT, also known as HIF1β) in the liver or pancreas leads to a dia...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wu, Rongxue, Chang, Hsiang-Chun, Khechaduri, Arineh, Chawla, Kusum, Tran, Minh, Chai, Xiaomeng, Wagg, Cory, Ghanefar, Mohsen, Jiang, Xinghang, Bayeva, Marina, Gonzalez, Frank, Lopaschuk, Gary, Ardehali, Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347233/
https://ncbi.nlm.nih.gov/pubmed/25329697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76737
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