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Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
Hexokinase-II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid to glucose, we hypothesized that a reduction in HKII would decrease cardiac hypertrophy after pressure overload. Con...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
WILEY-VCH Verlag
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3407950/ https://ncbi.nlm.nih.gov/pubmed/22517678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200240 |
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