Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling after Ischemia-Reperfusion Injury

RATIONALE: Cardiomyocytes switch substrate utilization from fatty acid to glucose under ischemic conditions, however, it is unknown how perturbations in glycolytic enzymes affect cardiac response to ischemia-reperfusion (I/R). Hexokinase (HK) II is a HK isoform that is expressed in the heart and it...

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Hlavní autoři: Wu, Rongxue, Smeele, Kirsten M., Wyatt, Eugene, Ichikawa, Yoshihiko, Eerbeek, Otto, Sun, Lin, Chawla, Kusum, Hollmann, Markus W., Nagpal, Varun, Heikkinen, Sami, Laakso, Markku, Jujo, Kentaro, Wasserstrom, J. Andrew, Zuurbier, Coert J., Ardehali, Hossein
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017633/
https://ncbi.nlm.nih.gov/pubmed/21071708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.223115
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