Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling after Ischemia-Reperfusion Injury

RATIONALE: Cardiomyocytes switch substrate utilization from fatty acid to glucose under ischemic conditions, however, it is unknown how perturbations in glycolytic enzymes affect cardiac response to ischemia-reperfusion (I/R). Hexokinase (HK) II is a HK isoform that is expressed in the heart and it...

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Autors principals: Wu, Rongxue, Smeele, Kirsten M., Wyatt, Eugene, Ichikawa, Yoshihiko, Eerbeek, Otto, Sun, Lin, Chawla, Kusum, Hollmann, Markus W., Nagpal, Varun, Heikkinen, Sami, Laakso, Markku, Jujo, Kentaro, Wasserstrom, J. Andrew, Zuurbier, Coert J., Ardehali, Hossein
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017633/
https://ncbi.nlm.nih.gov/pubmed/21071708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.223115
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