Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

Mitochondrially bound hexokinase II (mtHKII) has long been known to confer cancer cells with their resilience against cell death. More recently, mtHKII has emerged as a powerful protector against cardiac cell death. mtHKII protects against ischaemia-reperfusion (IR) injury in skeletal muscle and hea...

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Bibliografiske detaljer
Main Authors: Nederlof, Rianne, Eerbeek, Otto, Hollmann, Markus W, Southworth, Richard, Zuurbier, Coert J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
Fag:
Themed Issue: Mitochondrial Pharmacology: Energy, Injury & Beyond
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976622/
https://ncbi.nlm.nih.gov/pubmed/24032601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12363
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