PATHOPHYSIOLOGICAL CONSEQUENCES OF TAT-HKII PEPTIDE ADMINISTRATION ARE INDEPENDENT OF IMPAIRED VASCULAR FUNCTION AND ENSUING ISCHEMIA

RATIONALE: We have shown that partial dissociation of HKII from mitochondria in the intact heart using low dose (200 nM) TAT-HKII prevents the cardioprotective effects of ischemic preconditioning (IPC) whereas high-dose (10 μM) TAT-HKII administration results in rapid myocardial dysfunction, mitocho...

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Hlavní autoři: Nederlof, Rianne, Xie, Chaoqin, Eerbeek, Otto, Koeman, Anneke, Milstein, Dan MJ, Hollmann, Markus W, Mik, Egbert G, Warley, Alice, Southworth, Richard, Akar, Fadi G., Zuurbier, Coert J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596767/
https://ncbi.nlm.nih.gov/pubmed/23329797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.274308
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