Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production

Hexokinase-II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid to glucose, we hypothesized that a reduction in HKII would decrease cardiac hypertrophy after pressure overload. Con...

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Autores principales: Wu, Rongxue, Wyatt, Eugene, Chawla, Kusum, Tran, Minh, Ghanefar, Mohsen, Laakso, Markku, Epting, Conrad L, Ardehali, Hossein
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2012
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407950/
https://ncbi.nlm.nih.gov/pubmed/22517678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200240
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