Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

Mitochondrial iron levels are tightly regulated, as iron is essential for the synthesis of Fe/S clusters and heme in the mitochondria, but high levels can cause oxidative stress. The ATP-binding cassette (ABC) transporter ABCB8 is a mitochondrial inner membrane protein with an unknown function. Here...

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Detalhes bibliográficos
Main Authors: Ichikawa, Yoshihiko, Bayeva, Marina, Ghanefar, Mohsen, Potini, Vishnu, Sun, Lin, Mutharasan, R. Kannan, Wu, Rongxue, Khechaduri, Arineh, Jairaj Naik, Tejaswitha, Ardehali, Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306722/
https://ncbi.nlm.nih.gov/pubmed/22375032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119338109
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