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Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development

Transport of oxygen by red blood cells (rbc) is critical for life and embryogenesis. Here, we determined that provision of the lipid mediator sphingosine 1-phosphate (S1P) to the systemic circulation is an essential function of rbc in embryogenesis. Mice with rbc-specific deletion of sphingosine kin...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Xiong, Yuquan, Yang, Peiying, Proia, Richard L., Hla, Timothy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347220/
https://ncbi.nlm.nih.gov/pubmed/25250575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77685
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