Essential Role for Sphingosine Kinases in Neural and Vascular Development

Sphingosine-1-phosphate (S1P), an important sphingolipid metabolite, regulates diverse cellular processes, including cell survival, growth, and differentiation. Here we show that S1P signaling is critical for neural and vascular development. Sphingosine kinase-null mice exhibited a deficiency of S1P...

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Autori principali: Mizugishi, Kiyomi, Yamashita, Tadashi, Olivera, Ana, Miller, Georgina F., Spiegel, Sarah, Proia, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316977/
https://ncbi.nlm.nih.gov/pubmed/16314531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.11113-11121.2005
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