Essential Role for Sphingosine Kinases in Neural and Vascular Development

Sphingosine-1-phosphate (S1P), an important sphingolipid metabolite, regulates diverse cellular processes, including cell survival, growth, and differentiation. Here we show that S1P signaling is critical for neural and vascular development. Sphingosine kinase-null mice exhibited a deficiency of S1P...

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Bibliografiske detaljer
Main Authors: Mizugishi, Kiyomi, Yamashita, Tadashi, Olivera, Ana, Miller, Georgina F., Spiegel, Sarah, Proia, Richard L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316977/
https://ncbi.nlm.nih.gov/pubmed/16314531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.24.11113-11121.2005
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