CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases (HDAC) 1 and 2 as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of MHC class II-selected CD4(+) helper T ce...

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Publicado no:Nat Immunol
Main Authors: Boucheron, Nicole, Tschismarov, Roland, Goeschl, Lisa, Moser, Mirjam A., Lagger, Sabine, Sakaguchi, Shinya, Winter, Mircea, Lenz, Florian, Vitko, Dijana, Breitwieser, Florian P., Müller, Lena, Hassan, Hammad, Bennett, Keiryn L., Colinge, Jacques, Schreiner, Wolfgang, Egawa, Takeshi, Taniuchi, Ichiro, Matthias, Patrick, Seiser, Christian, Ellmeier, Wilfried
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346201/
https://ncbi.nlm.nih.gov/pubmed/24681565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2864
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