Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein (GP) and compete for binding to a single major antigenic site. Remarkably, several of the antibodies al...

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Publicado en:Cell
Main Authors: Flyak, Andrew I., Ilinykh, Philipp A., Murin, Charles D., Garron, Tania, Shen, Xiaoli, Fusco, Marnie L., Hashiguchi, Takao, Bornholdt, Zachary A., Slaughter, James C., Sapparapu, Gopal, Klages, Curtis, Ksiazek, Thomas G., Ward, Andrew B., Saphire, Erica Ollmann, Bukreyev, Alexander, Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344968/
https://ncbi.nlm.nih.gov/pubmed/25723164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.01.031
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