BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION

Ebola virus (EBOV) in humans causes a severe illness with high mortality rates. Several strategies have been developed in the past to treat EBOV infection, including the antibody cocktail ZMapp(TM) that has been shown to be effective in nonhuman primate models of infection(1) and has been used under...

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Udgivet i:Nat Microbiol
Main Authors: Flyak, Andrew I., Kuzmina, Natalia, Murin, Charles D., Bryan, Christopher, Davidson, Edgar, Gilchuk, Pavlo, Gulka, Christopher P., Ilinykh, Philipp A., Shen, Xiaoli, Huang, Kai, Ramanathan, Palaniappan, Turner, Hannah, Fusco, Marnie L., Lampley, Rebecca, Kose, Nurgun, King, Hannah, Sapparapu, Gopal, Doranz, Benjamin J., Ksiazek, Thomas G., Wright, David W., Saphire, Erica Ollmann, Ward, Andrew B., Bukreyev, Alexander, Crowe, James E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030461/
https://ncbi.nlm.nih.gov/pubmed/29736037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0157-z
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