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A Simple Fragment of the Cyclic Acyldepsipeptides is Necessary and Sufficient for ClpP Activation and Antibacterial Activity

The discovery of new classes of antibacterial agents, particularly those with unique biological targets, is essential to keep pace with emerging drug resistance in pathogenic bacteria. We identified the minimal structural component of the cyclic acyldepsipeptide (ADEP) antibiotics that exhibits anti...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Carney, Daniel W., Compton, Corey L., Schmitz, Karl R., Stevens, Julia P., Sauer, Robert T., Sello, Jason K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343535/
https://ncbi.nlm.nih.gov/pubmed/25212124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402358
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