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Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro
Proteolytic complexes in Mycobacterium tuberculosis (Mtb), the deadliest bacterial pathogen, are major foci in tuberculosis drug development programs. The Clp proteases, which are essential for Mtb viability, are high priority targets. These proteases function through the collaboration of ClpP1P2, a...
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| Udgivet i: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2023
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7842861/ https://ncbi.nlm.nih.gov/pubmed/32083462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00454 |
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