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Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in their Interaction with the ClpP Peptidase
The cyclic acyldepsipeptide (ADEP) antibiotics act by binding the ClpP peptidase and dysregulating its activity. Their exocyclic N-acylphenylalanine is thought to structurally mimic the ClpP-binding, (I/L)GF tripeptide loop of the peptidase’s accessory ATPases. We found that ADEP analogs with exocyc...
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| Publicado no: | Chembiochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992462/ https://ncbi.nlm.nih.gov/pubmed/26147653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500234 |
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