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Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in their Interaction with the ClpP Peptidase
The cyclic acyldepsipeptide (ADEP) antibiotics act by binding the ClpP peptidase and dysregulating its activity. Their exocyclic N-acylphenylalanine is thought to structurally mimic the ClpP-binding, (I/L)GF tripeptide loop of the peptidase’s accessory ATPases. We found that ADEP analogs with exocyc...
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| 出版年: | Chembiochem |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992462/ https://ncbi.nlm.nih.gov/pubmed/26147653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500234 |
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