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Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

Caseinolytic peptidase P (ClpP), a double-ring peptidase with 14 subunits, collaborates with ATPases associated with diverse activities (AAA+) partners to execute ATP-dependent protein degradation. Although many ClpP enzymes self-assemble into catalytically active homo-tetradecamers able to cleave s...

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מידע ביבליוגרפי
Main Authors: Schmitz, Karl R., Carney, Daniel W., Sello, Jason K., Sauer, Robert T.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217457/
https://ncbi.nlm.nih.gov/pubmed/25267638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417120111
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