Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in their Interaction with the ClpP Peptidase

The cyclic acyldepsipeptide (ADEP) antibiotics act by binding the ClpP peptidase and dysregulating its activity. Their exocyclic N-acylphenylalanine is thought to structurally mimic the ClpP-binding, (I/L)GF tripeptide loop of the peptidase’s accessory ATPases. We found that ADEP analogs with exocyc...

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Publicado en:Chembiochem
Main Authors: Carney, Daniel W., Schmitz, Karl R., Scruse, Anthony, Sauer, Robert T., Sello, Jason K.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992462/
https://ncbi.nlm.nih.gov/pubmed/26147653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500234
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