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Why Ser and not Thr brokers catalysis in the trypsin fold()
Although Thr is equally represented as Ser in the human genome and is as good a nucleophile, it is never found in the active site of the large family of trypsin-like proteases that utilize the Asp/His/Ser triad. The molecular basis of the preference of Ser over Thr in the trypsin fold was investigat...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4342846/ https://ncbi.nlm.nih.gov/pubmed/25664608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00014 |
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