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Kinetic Dissection of the Pre-existing Conformational Equilibrium in the Trypsin Fold
Structural biology has recently documented the conformational plasticity of the trypsin fold for both the protease and zymogen in terms of a pre-existing equilibrium between closed (E*) and open (E) forms of the active site region. How such plasticity is manifested in solution and affects ligand rec...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566218/ https://ncbi.nlm.nih.gov/pubmed/26216877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675538 |
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