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Kinetic Dissection of the Pre-existing Conformational Equilibrium in the Trypsin Fold
Structural biology has recently documented the conformational plasticity of the trypsin fold for both the protease and zymogen in terms of a pre-existing equilibrium between closed (E*) and open (E) forms of the active site region. How such plasticity is manifested in solution and affects ligand rec...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566218/ https://ncbi.nlm.nih.gov/pubmed/26216877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675538 |
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