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Loop electrostatics asymmetry modulates the pre-existing conformational equilibrium in thrombin
Thrombin exists as an ensemble of active (E) and inactive (E*) conformations that differ for their accessibility to the active site. Here we show that redistribution of the E*-E equilibrium can be achieved by perturbing the electrostatic properties of the enzyme. Removal of the negative charge of th...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5114853/ https://ncbi.nlm.nih.gov/pubmed/27347732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00385 |
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