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Rigidification of the autolysis loop enhances Na(+) binding to thrombin

Binding of Na(+) to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na(+) is weak due to large heat capacity and enthalpy changes...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pozzi, Nicola, Chen, Raymond, Chen, Zhiwei, Bah, Alaji, Di Cera, Enrico
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150630/
https://ncbi.nlm.nih.gov/pubmed/21536369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.04.003
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