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Rigidification of the autolysis loop enhances Na(+) binding to thrombin
Binding of Na(+) to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na(+) is weak due to large heat capacity and enthalpy changes...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150630/ https://ncbi.nlm.nih.gov/pubmed/21536369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2011.04.003 |
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