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Stabilization of the E* Form Turns Thrombin into an Anticoagulant
Previous studies have shown that deletion of nine residues in the autolysis loop of thrombin produces a mutant with an anticoagulant propensity of potential clinical relevance, but the molecular origin of the effect has remained unresolved. The x-ray crystal structure of this mutant solved in the fr...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740429/ https://ncbi.nlm.nih.gov/pubmed/19473969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012344 |
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