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Why Ser and not Thr brokers catalysis in the trypsin fold()

Although Thr is equally represented as Ser in the human genome and is as good a nucleophile, it is never found in the active site of the large family of trypsin-like proteases that utilize the Asp/His/Ser triad. The molecular basis of the preference of Ser over Thr in the trypsin fold was investigat...

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Foilsithe in:Biochemistry
Main Authors: Pelc, Leslie A., Chen, Zhiwei, Gohara, David W., Vogt, Austin D., Pozzi, Nicola, Di Cera, Enrico
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342846/
https://ncbi.nlm.nih.gov/pubmed/25664608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00014
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