Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

[Image: see text] Mycobacterium tuberculosis (Mtb) maintains its intrabacterial pH (pH(IB)) near neutrality in the acidic environment of phagosomes within activated macrophages. A previously reported genetic screen revealed that Mtb loses this ability when the mycobacterial acid resistance protease...

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Udgivet i:ACS Chem Biol
Main Authors: Zhao, Nan, Darby, Crystal M., Small, Jennifer, Bachovchin, Daniel A., Jiang, Xiuju, Burns-Huang, Kristin E., Botella, Helene, Ehrt, Sabine, Boger, Dale L., Anderson, Erin D., Cravatt, Benjamin F., Speers, Anna E., Fernandez-Vega, Virneliz, Hodder, Peter S., Eberhart, Christina, Rosen, Hugh, Spicer, Timothy P., Nathan, Carl F.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340348/
https://ncbi.nlm.nih.gov/pubmed/25457457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500746z
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