Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

BACKGROUND: The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from clonal evolution a...

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Udgivet i:PLoS Med
Main Authors: Schwarz, Roland F., Ng, Charlotte K. Y., Cooke, Susanna L., Newman, Scott, Temple, Jillian, Piskorz, Anna M., Gale, Davina, Sayal, Karen, Murtaza, Muhammed, Baldwin, Peter J., Rosenfeld, Nitzan, Earl, Helena M., Sala, Evis, Jimenez-Linan, Mercedes, Parkinson, Christine A., Markowetz, Florian, Brenton, James D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339382/
https://ncbi.nlm.nih.gov/pubmed/25710373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001789
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