Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

BACKGROUND: The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine whether intra-tumour genetic heterogeneity resulting from clonal evolution a...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Schwarz, Roland F., Ng, Charlotte K. Y., Cooke, Susanna L., Newman, Scott, Temple, Jillian, Piskorz, Anna M., Gale, Davina, Sayal, Karen, Murtaza, Muhammed, Baldwin, Peter J., Rosenfeld, Nitzan, Earl, Helena M., Sala, Evis, Jimenez-Linan, Mercedes, Parkinson, Christine A., Markowetz, Florian, Brenton, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339382/
https://ncbi.nlm.nih.gov/pubmed/25710373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001789
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