Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

BACKGROUND: Circulating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess tumour burden and response to treatment in cancer patients. Somatic TP53 mutations are a defining feature of high-grade serous ovarian carcinoma (HGSO...

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Detalhes bibliográficos
Publicado no:PLoS Med
Main Authors: Parkinson, Christine A., Gale, Davina, Piskorz, Anna M., Biggs, Heather, Hodgkin, Charlotte, Addley, Helen, Freeman, Sue, Moyle, Penelope, Sala, Evis, Sayal, Karen, Hosking, Karen, Gounaris, Ioannis, Jimenez-Linan, Mercedes, Earl, Helena M., Qian, Wendi, Rosenfeld, Nitzan, Brenton, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5172526/
https://ncbi.nlm.nih.gov/pubmed/27997533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1002198
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